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NITROSIGINE® From Nutrition21®

Accepted and used by athletes,
bodybuilders, and fitness enthusiasts
as a stimulant-free pre-workout

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Ingredient overview

Individuals consuming Nitrosigine® should experience significant increases in nitric oxide levels resulting in improved blood flow and oxygen delivery to stressed muscles. As a result, the training experience can be dramatically intensified with muscle pumps and increased vascularity.

Target Audience

Nitrosigine is widely accepted and used by bodybuilders, athletes, and gymgoers as a stimulant-free pre-workout with an emphasis on the pump experience!

Bottom Line

1.5 grams of stimulant-free Nitrosigine® (full clinical dose) is expected to dramatically impact your training and result in intense muscle pumps.

Product Highlights

  • Promote Increased NO Levels
  • Accelerate Recovery From Exercise
  • Boosts Muscle Pump
  • Improves Focus & Energy

As part of a pre-workout formula, consider prioritizing products with a  recommended serving dose of 1.5 grams, usually taken 20 minutes before a workout. However, some brands may suggest a split dose of 750 mg each which is also confirmed to work. Do not exceed 1.5g in a 24-hour period.

Nitrosigine can elevate arginine levels in the blood for a period of 6 hours. The amount of Nitrosigine needed to boost blood flow is 1.5g, equivalent to 8g of Citrulline. A single dose of Nitrosigine can quickly boost arginine levels in the blood within 30 minutes and sustain it for 6 hours. Nitrosigine aids in muscle recovery post-exercise
Most pre-workouts contain stimulants like caffeine. Be aware that the caffeine intake at 1 dose of 750 mg may be safe, at 2 doses the caffeine intake may be excessive. We strongly urge you to evaluate the effectiveness of the product at a single dose of 750 mg and more importantly make sure the stimulant dose isn’t excessive.


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It is important to note that the content on Genmag is not intended to diagnose, treat, prevent, or reverse any physical or medical condition. Although our articles may a number of topics including specialty ingredients that can benefit various health goals, they are not a replacement for a balanced diet and healthy lifestyle habits. We strongly recommend consulting a doctor before taking any health supplement or beginning an exercise program, particularly if you have a pre-existing medical condition or take medication. Supplements can interact with certain medications and affect their effectiveness.

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